Afteranexperimentaldrugtrialgoeshorriblywrong,thesurvivingtestsubjectshavetofightoffsleep,andeachother,tostayalive.

It was the age of Da Vinci and Michelangelo, of enlightened creativity and unparalleled intellectual achievement. But it was also the age of Machievelli, of rampant lawlessness, incessant war and unspeakable depravity. At the heart of the world order was the Vatican, the arbiter of conflicts between kingdoms and empire…

波吉亚家族第三季的剧情跨越十年，讲述了随着意大利迈向新世纪，波吉亚家族的兴旺：Cesare通过教宗国的征服之路渐露曙光，Lucrezia试图按自己的意愿执掌罗马，而Rodrigo，这位年事已高的亚历山大六世教皇，努力不让年龄摧毁他的力量。